The fifth-ranked gene, ANO3, is associated with impaired anoctamin function, which can lead to a wide range of disorders, such as hearing loss, bleeding disorders, ataxia and dystonia, persistent borrelia and mycobacterial infections, skeletal syndromes, such as jaw stem dysplasia and limb girdle muscular dystrophy, and cancer. This evidence concerns the gene ANO3 and limb-girdle muscular dystrophy.