Females with proximal CRC showed a significant association with dMMR/MSI-high and high EGFR expression (OR 14.93, 95% CI 1.27–176.05, P = 0.032; and OR 4.17, 95% CI 1.28–13.56, P = 0.017, respectively), while PD-L1 expression was inversely correlated to males with proximal CRC with a CPS cutoff of 1 (OR 0.28, 95% CI 0.09–0.91, P = 0.034) (Table 5). Here, CD274 is linked to colorectal carcinoma.