The findings from this systematic review and meta-analysis with 4 studies and enrolling a combined total of 160 patients show significantly increased levels of circulating heparan sulfate fragments and glycoproteins (ICAM-1, VCAM-1, P-selectin, and E-selectin) in sepsis patients with SAE compared to sepsis patients without SAE. The gene discussed is SELE; the disease is Sepsis.