Analysis of other baseline characteristics of patients with pSSN showed significantly higher age at onset (p < 0.0001) and at diagnosis (p < 0.0001), more frequent initial presentation via hospitalization (p < 0.001), and significantly less frequent SSA(Ro) antibody positivity (p = 0.03) than patients with pSS without neurologic involvement. This evidence concerns the gene CALR and peeling skin syndrome.