TAFAZZIN and dilated cardiomyopathy: While Taz-KO mice are characterized by embryonic lethality, impaired growth, and dilated cardiomyopathy with severe systolic dysfunction [79], Taz-KD exhibit only a mild reduction in LVEF and a limited inotropic reserve, recapitulating the phenotype of those Barth syndrome patients who do not develop (or recover from) severe HF during infancy [80••].