GSDMD and acute kidney injury: In particular, AKI-induced mitochondrial reactive oxygen species (mROS) promote the activation of the NLRP3 inflammasome, leading to caspase 1-dependent production of gasdermin D (GSDMD)-mediated pyroptosis and the maturation of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 [14–16].