Furthermore, we utilised existing total RNAseq data from a clinically well-defined, seropositive, uniformly-treated, cohort of 19 early RA patient biopsy samples, pre- and post- 6-months of triple disease modifying anti rheumatic drug (tDMARD) treatment15, and assessed for gene expression profiles of PD-1+ cells within the ST. This evidence concerns the gene PDCD1 and rheumatoid arthritis.