LMNA::NTRK1 fusion represents the most common genetic alteration in lipofibromatosis-like neural tumors, a recently described entity with predilection for children and characterized by monomorphic spindle cell phenotype, infiltrating growth pattern, and often co-expression of S100 and CD34 immunomarkers [3, 6]. The gene discussed is NTRK1; the disease is nervous system cancer.