NTRK1 and nervous system cancer: Moreover, some studies have shown that NTRK genotype may correlate with tumor phenotype and risk of malignancy, with NTRK1 intrachromosomal rearrangements (interstitial deletions or inversions) occurring in most benign lipofibromatosis-like neural tumors [3], while ETV6::NTRK3 fusions driving overwhelmingly malignant lesions [2].