Similarly, PAR-2 cell surface expression on monocytes was significantly increased in patients with GPA (4.79%, IQR 4.64–5.09) compared with HC (2.98%, IQR 2.05–3.71) and patients with MPA (3.21%, IQR 2.92–3.77) (both p<0.01, one-way ANOVA). Here, F2RL1 is linked to granulomatosis with polyangiitis.