SMARCA4 and cancer: We also observed significant enrichment of matrisome and extracellular matrix–associated genes in the iBRG1 set (Fig S1, middle and bottom), suggesting there are BRG1-driven gene expression signatures that are highly implicated in cancer metastasis and the tumor microenvironment (Yuzhalin et al, 2018; Socovich & Naba, 2019).