While the use of a combination of MCEMP1 and HLA-DRA did not significantly affect AUC values as compared to MCEMP1 and HLA-DRA alone, combination of both genes showed significantly higher AUCs than with HLA-DRA alone in the Carapito et al., 2022 dataset,26 suggesting that the combination of both of MCEMP1 and HLA-DRA could be more suitable for severe COVID-19 prognosis (Supplementary Fig. S2, Supplementary Table S4). The gene discussed is HLA-DRA; the disease is COVID-19.