These results are in consistent with previous findings documenting that severe COVID-19 is associated with the appearance of dysfunctional HLA-DRlo CD163hi and HLA-DRlo S100Ahi CD14+ inflammatory monocytes, which may elevate immature and dysfunctional neutrophil frequencies48 and CD4+ T cell leukopenia.32 This evidence concerns the gene CD14 and Decreased total leukocyte count.