In conclusion, through systematic review and re-analysis of data from a total of 140 severe and 181 severe COVID-19 patients from 7 independent RNAseq datasets, time-series analysis and single cell sequencing RNAseq datasets, we identified that early MCEMP1 and HLA-DRA peripheral blood expression to be highly associated with progression to severe COVID-19. This evidence concerns the gene HLA-DRA and COVID-19.