ANOVAs revealed a significant effect of treatment time on BC, UA,TC,TG,HDL,LDL,FBG,PRL (F = 22.84, P < 0.001; F = 4.13, P = 0.043; F = 57.84, P < 0.001; F = 78.42, P < 0.001; F = 64.98, P < 0.001; F = 10.67,P = 0.001; F = 74.58, P < 0.001; F = 30.77, P < 0.001; respectively), a significant negative effect of early non-response to treatment on AC,BC,TG,FBG (F = 6.84, P = 0.009; F = 7.88, P = 0.005; F = 16.39, P < 0.001; respectively) and a significant effect of time × subgroup interaction on TG (F = 10.16, P = 0.002) (Table 5). Here, PRL is linked to breast cancer.