CRP and obesity due to melanocortin 4 receptor deficiency: We had already demonstrated in a previous uncontrolled, single - center, open - label pilot clinical study in 260 women with overweight or obesity that hs - CRP levels decreased (∆-38.9 ± 45.6%) while PhA increased (∆+8.6 ± 12.5%) after 31 days of an active phase of VLCKD [42].