CREB1 and cancer: In this study, sesamin, quercetin, bicuculline, kaempferol, luteolin, and ginkgolide B were identified as important herbal compounds, and EGFR, CREB1, PTGS2, PPARG, PPARA, MMP9, MAPK8, and MAPK14 were identified as major protein targets for the treatment of CA.