KRAS and lung carcinoma: On November 9, 2021, the results of gene detection in lung cancer tissues showed that the gene G12D of KRAS was mutated, and PD- L1 was positive (22C3 TPS was 95%) (Fig. 2B), while EGFR, ALK, MET, ROS1, RET, HER2, BRAF, NTRK, NRAS, and PIK3CA were all negative.