Moreover, many studies have shown that the PI3K-Akt signaling pathway is involved in the regulation of apoptosis in ITP, but the function of mutation gene in ITP pathogenesis remains to be elucidated fully and little is known about the concrete transcription process or protein expression pathogenesis of mutation genes leading to thrombocytopenia. This evidence concerns the gene AKT1 and autoimmune thrombocytopenic purpura.