Several DNA polymorphisms induced by SNPs played an important role in the pathogenesis of ITP.[16,17] Rischewski’s group proposed that the existence of genetic susceptibility to ITP by describing positive familial history in pediatric ITP cases.[2] Our previous research about quantitative proteomics analysis has shown that apoptosis-related proteins[18] and autophagy-related proteins were significantly expressed abnormal in ITP BMBMC samples compared to normal controls. Here, FAM215A is linked to autoimmune thrombocytopenic purpura.