To show evidences of early inflammasome sensing of HIV-1 in huNSG mice upon HIV-1 infection, we quantified mRNA expression of genes involved in inflammasome activation (NLRP3, NLRP1, NLRC4, AIM2, IFI16, ASC, CASP1, IL1Β, and IL18) in hCD45+ cells from multiple tissues collected at necropsy. The gene discussed is NLRP3; the disease is HIV-1 infection.