In contrast, caspase-1 inhibition blunted the amplitude of the HIV-1 induced cytokine storm as VX-765 treated huNSG mice only upregulated significantly the levels of IP-10 and TNF-α after infection (p<0.05 and 0.05, respectively; Figure 4—figure supplement 1E and F). The gene discussed is CXCL10; the disease is infection.