KRAS and colorectal carcinoma: We suggest that STK1p should be combined with TNM stage and specific serum biomarkers with high sensitivity for identifying early-stage precancerous lesions located in the L-CC, R-CC or RC, such as K–ras mutations and TK1 histochemical high staining of suspect polyps/precancerous lesions, to further improve the early prognosis of CRC-different entities patients.