Twelve (60%) patients developed concurrent non-neurologic irAEs, involving one (n = 6) or more than one (n = 6) organs (myocarditis, n = 4; thyroiditis, n = 4; hepatitis, n = 4; dermatitis, n = 3; adrenal insufficiency, n = 2; enterocolitis, n = 1; type 1 diabetes mellitus with anti-GAD antibodies, n = 1). This evidence concerns the gene GAD1 and Hepatitis.