The aim of this study was to compare a B cell- and plasma cell-based immune cell scoring system (based on CD20+ B cell and CD138+ (SDC1+) plasma cell densities in the tumor center and invasive margin) to the T cell score (based on CD3+ and CD8+ T cell densities in the tumor center and invasive margin, following the main principles of the Immunoscore®) and explore their prognostic value in colorectal cancer. The gene discussed is SDC1; the disease is colorectal cancer.