CD8 T cells have conflicting roles in chlamydial infections, having been shown to cause immunopathology, predominantly through the production of TNFα [59], but in some cases also protection through atypical Chlamydia-specific cells secreting IL13 in addition to TNFα, IFNγ, and IL10 [60, 61]. This evidence concerns the gene IL10 and chlamydia trachomatis infectious disease.