Dysregulation of proteins including Rpl27, Oxct1, and Snrpn, as seen here, associates with human sperm immobility and infertility, which not only provides a molecular quantifier for vaccine-mediated protection of sperm but also shows the mouse model mimics the human disease state, useful in studying the Chlamydial disease and vaccine development. The gene discussed is RPL27; the disease is chlamydia trachomatis infectious disease.