Dysregulation of proteins including Rpl27, Oxct1, and Snrpn, as seen here, associates with human sperm immobility and infertility, which not only provides a molecular quantifier for vaccine-mediated protection of sperm but also shows the mouse model mimics the human disease state, useful in studying the Chlamydial disease and vaccine development. Here, SNRPN is linked to chlamydia trachomatis infectious disease.