To approach how also the PKM2 downstream activities were affected in the degenerating photoreceptors, we next studied how a known PKM2 target, namely glucose transporter-1 (Glut1; Luo& Semenza, 2012), which is essential for rod photoreceptors (Daniele et al., 2022), was expressed in the RP models. The gene discussed is SLC2A1; the disease is retinitis pigmentosa 1.