In conclusion, while many questions with respect to PKM2 and photoreceptor degeneration remain to be answered, like if its retinal substrates are the same as in other tissues, and if this changes in disease, as well as if PKM2 inhibition of WT explants will mimic the degenerative outcome of genetic deletion of the enzyme (Rajala et al., 2018), the results from our study shed light on a potential, novel molecular target that may exert a direct effect on RP. This evidence concerns the gene PKM and retinitis pigmentosa 1.