We hypothesized that PKM2 may work as one of the cGMP-PKG downstream targets in RP and here approached this with the aid of two RP models, rd2 and rd10, that both have an abnormally high level of photoreceptor cGMP (Arango-Gonzalez et al., 2014; Paquet-Durand et al., 2009; Yang et al., 2020). This evidence concerns the gene PKM and retinitis pigmentosa 1.