To do so we added 6-((3-Aminophenyl)methyl)-4-methyl-2-methylsulfinyl­thieno[3,4]-pyrrolo[1,3-d]pyridazin-5-one (TEPP-46, a PKM2 activator) (Jiang et al., 2010) during organotypic retinal explant culturing with tissue from either the rd2 or the rd10 mouse strains (Chang et al., 2002), two RP models where photoreceptor cGMP is high (Arango-Gonzalez et al., 2014). This evidence concerns the gene PRPH2 and retinitis pigmentosa 1.