Intriguingly, MNPs@FMN reduced the Aβ plaque burden (stained by 6E10) (FC = 0.556, p = 0.0061; FC = 0.622, p = 0.0439), and increased the numbers of microglia engulfing Aβ (FC = 1.463, p = 0.0441; FC = 1.463, p = 0.0441) in the hippocampus, together with decreased microglial RFK expression in the AD model (FC = 0.321, p = 0.0050; FC = 0.374, p = 0.0385), as compared with AD‐PBS and AD‐FMN (Figure 11K–O). This evidence concerns the gene RFK and Alzheimer disease.