Low intake of riboflavin has been correlated with the development of cognitive impairment, and studies suggest that cognitive function in middle‐aged and elderly people may be improved by dietary intake of riboflavin and other forms of vitamin B.[16] Notably, the cognitive protection of riboflavin may be associated with its anti‐oxidative and anti‐inflammatory effects.[9] As a key enzyme in riboflavin metabolism, RFK has been shown to couple with TNFR1 to active NADPH oxidase,[11] suggesting that it may play a role in mediating the anti‐inflammatory effects of riboflavin. This evidence concerns the gene TNFRSF1A and Cognitive impairment.