FMN was previously reported to prevent Aβ toxicity by increasing ATP and NADH generation.[10] Moreover, our lab demonstrated that FMN protects DA neurons from oxidative stress in the PD mouse model.[17] In the present study, we report that FMN, but not FAD, improves inflammation‐based cognitive function by regulating the TNFR1/NF‐κB pathway. Here, TNFRSF1A is linked to Parkinson disease.