In this study, epigenetic abnormalities were the most prominent in ML, where TET2, ASXL1, GATA2, and FLT3 had the highest mutation frequency (≥20%), followed by NPM1, NRAS, and DNMT3A (10%–20%); the results were slightly different from those of previous studies; however, these genes are common in AML. The gene discussed is NPM1; the disease is acute myeloid leukemia.