BDNF and Mental deterioration: Therefore, it is reasonable to hypothesize that restoring the neurotrophic pathway via viral vectors that produce NGF and BDNF, or through neurotrophins receptor agonists, may counteract neuronal deterioration and attenuate synaptic degeneration, thus improving cognitive decline, as proposed by some clinical studies (Graham et al., 2017; Castle et al., 2020; Ruiz-González et al., 2021; Eyjolfsdottir et al., 2022).