IGF1 and Mental deterioration: We hypothesized that cognitive function would be reduced due to stress-related structural changes in the brain (Liston et al., 2009), and this cognitive decline was expected to be reflected by a decrease of neurotrophic factors BDNF and IGF-1, as these factors are highly associated with cognitive function (Saatman et al., 1997; Prokopova et al., 2017; Sungkarat et al., 2018).