According to the Sydney classification criteria, for definitive diagnosis of APS, elevated levels of anti-β2-glycoprotein I (aβ2GPI), anticardiolipin (aCL), and/or lupus anticoagulants (LAs) should be documented after a clinical event in 2 tests separated by at least 12 weeks [3]. Here, ACLY is linked to autoimmune polyendocrinopathy.