Moreover, many genes related to an accumulation of T cells (Cd8a, Cd3e, Cd4), inflammations (Cxcl9, Tnf, Ifng), and a subset of M1-macrophage (Ciita, Nos2, Cd86) have elevated in anti-PD-1 antibody-treated IL-34KO CT26 tumor. This evidence concerns the gene PDCD1 and neoplasm.