In the study of Pan (87) et al, they found that TsIIA significantly inhibits the activity of HSCs in rats and leads to HSC apoptosis, which is related to the changes in the expression of proteins related to the regulation of cell apoptosis (PARP, caspase-3, and Bax/Bcl-2 protein ratio increase) and cell cycle (cyclins A, E, and cdk2) in HCC after pretreatment with TsIIA (40). This evidence concerns the gene BCL2 and hepatocellular carcinoma.