It includes regulating the miR30b-p53 PTPN11/SHP2 pathway to induce the death of liver cancer cells (20), up-regulating the expression of miR-205 in ovarian cancer cells to induce apoptosis (169), targeting the metabolic regulation of miR-122/PKM2 to treat esophageal cancer, and inhibiting the expression level of microRNA-155 in colon cancer to inhibit colon cancer (170). This evidence concerns the gene PKM and colonic neoplasm.