The preliminary results of enrolled 75 patients showed that among clinically high-risk pN1 BC, which is defined as having at least two of the five clinical risk factors (age≤40, three positive LN(lymph node), T2 stage, grade 3, and Ki-67 index≥14%), 70% of them present with genomic high risk, and 30% present with genomic low risk, and whether those clinical high-risk but genomic low-risk BC patients could be omitted from IMNI still needs long-term follow-up of our research (47). The gene discussed is MKI67; the disease is breast cancer.