miR-623 inhibits interleukin-8- (IL-8-) induced epithelial interstitial transformation of pancreatic cancer cells by inhibiting extracellular regulatory protein kinase (ERK) phosphorylation, demonstrating the important role of miR-623 in inhibiting in vitro migration and invasion of pancreatic cancer cells and in vivo metastasis [11]. This evidence concerns the gene EPHB2 and familial pancreatic carcinoma.