HLA-A2 transgenic mice (Tgm) were used to identified KIF20A-derived and HLA-A2-restricted mouse CTL epitopes, KIF20A-2, KIF20A-8 and KIF20A-28 could induce HLA-A2-restricted CTLs in HLA-A2 Tgm without autoimmunity. This evidence concerns the gene KIF20A and Autoimmunity.