ESR1 and alkaline phosphatase measurement: According to the degree value, the top 8 targets (TNF, IL-1β, PPARγ, PPARα, PTGS2, NCOA1, CNR1, and ESR1) of the PPI network were identified as the core therapeutic targets with the degree value greater than or equal to 24, suggesting that these targets may play a crucial role in the network of MVO in AP treatment.