Based on the network topological analysis, GO and KEGG analysis, there were 8 targets (TNF, IL-1β, PPARγ, PPARα, PTGS2, NCOA1, CNR1, and ESR1) and 4 signaling pathways (neuroactive ligand-receptor interaction, estrogen, MAPK, and calcium signaling pathway) which have a very close association with the MVO in AP treatment. This evidence concerns the gene TNF and alkaline phosphatase measurement.