EGFR and non-small cell lung carcinoma: EGFR variant testing should be conducted for common EGFR TKI-sensitizing variants (e.g., Ex19del or p.Leu858Arg in exon 21) in eligible patients with metastatic NSCLC and for patients with resectable stages IB to IIIA NSCLC [4,13,19,20,21,38].