1.Hyperinsulinemic hypoglycemia: blood glucose levels and GTT↓,plasma insulin and glucagon levels↑2. mRNA levels of Kir6.2, Sur1, Kcnb1, Ffar2, Hadhsc, Ddc, Pdx1, SHP↓, Glut5, DCK, PDK1,HNF4α, PGC1α, CREB, Nrip1, Ch.B, Prka1a, VAPB, Mtac2, Rasgrp1, Myh10↑. The gene discussed is CREB1; the disease is hyperinsulinemic hypoglycemia.