INS and metabolic dysfunction-associated steatotic liver disease: There is now growing evidence that the FOXA family plays a role in the development of organs closely related to metabolism: the liver and pancreas, and that the FOXA family also has a complex and extensive network of regulatory roles in multiple aspects of glucose and lipid metabolism, including glucagon and insulin secretion, fatty acid and triglyceride metabolism, and several pathogenic processes of NAFLD as described above.