LDLR and neoplasm: As mentioned before, because large amounts of lipoproteins are required for rapid tumor proliferation, many malignancies increase LDL acquisition by upregulating LDLR.31 Therefore, the use of compounds that combine various drugs with LDL can induce tumor cell death at target sites.103 Compared with free drugs, drug-loaded LDL can target tumor cells more precisely and efficiently, significantly reducing the side effects caused by drugs in non-tumor sites.