As mentioned earlier, it is distributed in many different tissues and organs of the body.38 By contrast, LDLR is relatively abundant in the liver and kidney to promote their normal uptake and utilization of LDL.39 Therefore, although the upregulation of LDLR expression in tumor tissues is conducive to the targeted delivery of LDL, the LDLR expression in normal organs affects this specific tumor-targeting effect. Here, LDLR is linked to neoplasm.