Additionally, we found that pDC depletion abrogated the increase in IL-12/23 and IL-6 induced by CpG-ODN treatment (Fig 4C); both key cytokines that promote Th17 differentiation, suggesting that pDCs are at least in part required for inducing Th17 responses after CpG-ODN treatment in LAM. The gene discussed is IL6; the disease is lymphangioleiomyomatosis.