TNF-alpha signaling via NF-kB, IL6/JAK/STAT3 signaling, PI3K/AKT/mTOR signaling, MYC targets v2, TGF-beta signaling, and Kras signaling were mostly negatively correlated with LRRC3B expression, consistent with silencing of LRRC3B in tumor tissue, which may result in carcinogenesis. Here, TNF is linked to neoplasm.