TNF-alpha signaling via NF-kB, IL6/JAK/STAT3 signaling, PI3K/AKT/mTOR signaling, MYC targets v2, TGF-beta signaling, and Kras signaling were mostly negatively correlated with LRRC3B expression, consistent with silencing of LRRC3B in tumor tissue, which may result in carcinogenesis. The gene discussed is IL6; the disease is neoplasm.