Our data suggest that LRRC3B is a putative tumor suppressor gene across multiple cancers, including in BRCA, bladder urothelial carcinoma (BLCA), kidney renal clear cell carcinoma (KIRC), skin cutaneous melanoma (SKCM), lung adenocarcinoma (LUAD), and COAD. The gene discussed is LRRC3B; the disease is cancer.