Because of the above-mentioned importance of VEGF in diabetes and in corneal wound healing response, VEGF level was measured in our experiments and was found to be suppressed in diabetic mice after injury, suggesting that while sustained high levels of VEGF in the serum may correlate with the development of microvascular complications, post-injury tear VEGF levels may be important in the cornea wound healing response. This evidence concerns the gene VEGFA and diabetes mellitus.