Monocytes/macrophages are mediators of CRS and can be responsible for the release of IL-6, IL- 1, ferritin, and INF- γ, which results in endothelial activation and the secretion of von Willebrand factor (VWF) and angiopoietin-2 from endothelial cells. The gene discussed is VWF; the disease is congenital rubella syndrome.