Th17 cells and IL-17 can influence the process of tumor through various mechanisms, including immune infiltration, promotion of cancer cell invasion and metastasis, etc. A study identified related genes (KRT23, ULBP2, ASRGL1, SERPINA1, SCIN, SLC28A2) that may affect the immune infiltration of Th17 cells in COAD patients and suggested that the effect of these genes on Th17 cells may be responsible for their dual product (45). Here, IL17A is linked to cancer.