PDCD1 and neoplasm: Conversely, PDA primary tumors had greater PD-1+ICOS- CD8+ TRM (CP5, Supplementary Figures 8B–D) and PD-1hiTIGIT+CD57+ senescent CD4+ memory T cells (C4, Supplementary Figures 8F–H), suggesting a more chronic exhausted and/or senescent state in the primary tumor compared to liver metastasis.