Among the proteins, APOE, CLU, CHL1, SLC1A3, RAB7A, and CST3 were related to the protein aggregation of misfolded proteins—causative agents and symptomatic of neurodegenerative diseases—such as α-synuclein in PD, and amyloid-β and tau in dementia [99]. The gene discussed is APOE; the disease is dementia.