Taken together, the deleterious effects observed in the testes of COVID-19 patients, i.e., fibrosis, vascular alteration, inflammation, tunica propria thickening, Sertoli cell barrier loss, germ cell apoptosis, and inhibition of Leydig cells, seem to be associated with elevated angiotensin II and activation of mast cells and macrophages (Fig. 7a). This evidence concerns the gene AGT and COVID-19.