As mentioned in the aforementioned assays, we found that cSERPINE2 and MALT1 expression was significantly decreased in the TAMs educated by exosomes of the tumor cells pretreated with si-cSERPINE2-NPs (TAM si−cSERPINE2−NPs−Exo) compared to TAMs educated by exosomes of the tumor cells pretreated with si-ctrl-NPs (TAMsi−ctrl−NPs−Exo) (Fig. 7h and Supplementary Fig. S7b-d). The gene discussed is MALT1; the disease is neoplasm.