STAT3 and neoplasm: Nevertheless, ectopic expression of cSERPINE2 in MCF-7 cells did not regulate the expression of EIF4A3 or CCL2 or activation of the JAK2-STAT3 pathway, which indirectly indicated that cSERPINE2 overexpression did not affect tumor cell proliferative and invasive capacity in vitro (Supplementary Fig. S6b-d).