Tumor exosomal cSERPINE2 was shuttled to TAMs and notably elevated MALT1 level, and then enhanced the secretion of IL-6 through activating NF-\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\upkappa$$\end{document}κB pathway, leading to increasing proliferation and invasion of breast cancer cells. The gene discussed is IL6; the disease is breast cancer.