PFKFB3 and neoplasm: On top of this, Wang and his colleagues demonstrated that a 31-nts tRNAiMet fragment (tDR-1:31-iMet-CAT-1-M9 or tRiMetF31) from miR-34a-guided cleavage inhibited cell proliferation and angiogenesis by directly targeting PFKFB3 in neuroblastoma and breast cancer, which provides a new perspective on the inhibitory role of the miR-34a tumor suppressor network in tumor progression [72, 73].