Among them, tRNA halves, also known as tRNA-derived stress-induced RNAs (tiRNAs), which are 31–40 nts long RNA strands generated by angiogenin (ANG) responsible for cleaving the anticodon loop of mature tRNAs under stressful conditions (such as hypoxia, lack of amino acids, oxidative stress, ultraviolet radiation, heat shock, and viral infection) [19–22]. This evidence concerns the gene ANG and viral infectious disease.