In one study, LINC01559 was found to be downregulated in CRC compared to normal tissues and lower expression of LINC01559 in CRC patients indicated a poor prognosis; this study revealed the mechanism as negative regulation of the LINC01559/miR-106b-5p/PTEN axis in CRC progression and disclosed a new mechanism of METTL3-mediated m6A modification on LINC01559 [82]. Here, PTEN is linked to colorectal carcinoma.