H19 and cancer: Studies have found that H19 can promote the stemness of cancer stem cells (CSCs) and chemoresistance of CRC cells in CRC, and the mechanism is that CAFs could promote CRC stemness and chemoresistance by transferring H19 in exosome, H19 could activate the β-catenin signaling trough acting as a competing endogenous RNA sponge for miR-141, while miR-141 has the function to inhibit CRC stemness [20].