Ma et al. reported that lncRNA CCAL could activate the Wnt/β-catenin signal through inhibition of AP-2α and regulates MDR1/p glycoprotein expression and thus CRC development by activating the Wnt signaling pathway, MDR1/p glycoprotein was thought to be strongly related to multidrug resistance [4]. This evidence concerns the gene ABCB1 and colorectal carcinoma.