WDR5 and colorectal carcinoma: Another study showed that SATB2-AS1 could inhibit metastasis of CRC cells and regulates Th1-type chemokine expression and immune cell density in CRC tissues; SATB2-AS1 could directly bind to WDR5 and GADD45A, and mediate the deposition of H3K4me3 in the SATB2 promoter region and DNA demethylation, thereby activating SATB2 cis-transcription [77].