In addition, Ohtsuka et al. showed that H19 could affect RB1 phosphorylation by regulating CDK4 and CCND1 expression, and interact with CDK8 gene transcription regulator macroH2A to regulate CDK8 expression and influence β-catenin activity to promote the progression of CRC [21]. This evidence concerns the gene CDK8 and colorectal carcinoma.