Several lines of research suggested that sEV-mediated intercellular cargo delivery from chemoresistant BC cells to sensitive cells might induce a chemoresistant phenotype in the acceptor cells, including GSTP1 [164], UCH-L1 [165], and transient receptor potential channel 5 (TrpC5) [166] proteins in adriamycin-resistant BC cells and serum. This evidence concerns the gene UCHL1 and breast cancer.