ERBB2 and breast cancer: The Sub-ExoProfile chip is a microfluidic nanodevice with three self-assembled 3D nanopillars to capture CD81, EpCAM, and HER2-specific sEVs and tested in BC cell lines and plasma samples where it was capable of distinguishing HER2+ BC and triple-negative BC (TNBC) using a small volume of sample [73].