For example, Kirsten rat sarcoma viral oncogene homolog gene (KRAS) and epidermal growth factor receptor (EGFR) DNA mutations detected in plasma sEVs were reported to be sensitive tumour prognostic indicators for pancreatic cancer [54], early-stage non-small-cell lung cancer [55], colorectal cancer, and melanoma [56]. This evidence concerns the gene EGFR and melanoma.