In the same way, high abundance of ABCG2/breast cancer resistance protein (BCRP) in plasma sEVs isolated from anthracycline-taxane-based neoadjuvant chemotherapy-resistant BC patients [167], and annexin A6 in gemcitabine-resistant BC cells was found to transfer to chemo-sensitive BC cells via sEVs and induce chemoresistance [168]. Here, ANXA6 is linked to breast cancer.