Previous studies in small samples have shown that low expression of \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\alpha$$\end{document}α-Klotho is associated with the development of anemia in patients with chronic kidney disease and is also involved in activating the HIF signaling pathway, increasing serum EPO and iron levels [25]. The gene discussed is KL; the disease is anemia (phenotype).