The fifth edition of the “WHO Classification of Thoracic Tumors” mentioned three thymic cortical and three medullary epithelial markers, which are β5t, Thymus-specific serine protease 16 (PRSS16), cathepsin V, autoimmune regulator (AIRE), CD40 and claudin-4, but no indication was given about their roles in histological classification [1]. This evidence concerns the gene AIRE and neoplasm of thorax.